3-Fluoroaniline → HCID 18001927, compound

HRID 1017308Notes

Reaction equation

HRID 1017308 reaction equation
[Cl:1][C:2]1[N:10]=[C:9]2[C:5]([N:6]=[CH:7][N:8]2[CH:11]2[CH2:15][CH2:14][CH2:13][CH2:12]2)=[C:4](Cl)[N:3]=1.[F:17][C:18]1[CH:19]=[C:20]([CH:22]=[CH:23][CH:24]=1)[NH2:21]>C(N(CC)CC)C>[Cl:1][C:2]1[N:10]=[C:9]2[C:5]([N:6]=[CH:7][N:8]2[CH:11]2[CH2:15][CH2:14][CH2:13][CH2:12]2)=[C:4]([NH:21][C:20]2[CH:22]=[CH:23][CH:24]=[C:18]([F:17])[CH:19]=2)[N:3]=1

Participants

4

Reactant 2

HCID 97423-FluoroanilineHCID 108011162,6-dichloro-9-cyclopentyl-9H-purine

Product 1

HCID 18001927HCID 18001927, compound

Reagents, catalysts & solvents 1

HCID 8471TriethylamineSolvent

Procedure

2-Chloro-6-(3-fluorophenylamino)-9-cyclopentylpurine is prepared from 2,6-dichloro-9-cyclopentylpurine, 3-fluoroaniline, and triethylamine essentially as described above in Example 1, Scheme A, step b.

Sources & evidence

ORD record
ord-4347d36fac804cc0b00a5e81adcf75f2
Source dataset
uspto-grants-2002_11
Patent number
US06479487B1

Reaction notes

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