反应详情

Dissolve 1-(4-chlorobenzyl)-4-piperidone (0.0456 mmol), hydroxylamine hydrochloride (0.0456 mmol) and sodium acetate (0.0456 mmol) in aqueous ethanol (450 mL). Stir approximately 30 minutes to 2 hours while warming. Add methylene chloride (450 mL), separate the organic phase, and extract the aqueous phase with methylene chloride (100 mL). Combine the organic phases and dry (MgSO4). Evaporate the solvent in vacuo to give the title compound.

1. temperaturewhile warming
2. customAdd methylene chloride (450 mL), separate the organic phase
3. extractionextract the aqueous phase with methylene chloride (100 mL)
4. dry with materialCombine the organic phases and dry (MgSO4)
5. customEvaporate the solvent in vacuo