Hydroxyamine hydrochloride → 1-(2-Chlorobenzyl)-4-piperidone oxime

HRID 1017334Notes

Reaction equation

[Cl:1][C:2]1[CH:15]=[CH:14][CH:13]=[CH:12][C:3]=1[CH2:4][N:5]1[CH2:10][CH2:9][C:8](=O)[CH2:7][CH2:6]1.Cl.[NH2:17][OH:18]>>[Cl:1][C:2]1[CH:15]=[CH:14][CH:13]=[CH:12][C:3]=1[CH2:4][N:5]1[CH2:10][CH2:9][C:8](=[N:17][OH:18])[CH2:7][CH2:6]1

Participants

Reactant 2

HCID 443297Hydroxyamine hydrochloride

HCID 119595311-[(2-Chlorophenyl)methyl]piperidin-4-one

Product 1

HCID 126418231-(2-Chlorobenzyl)-4-piperidone oxime

Procedure

1-(2-Chlorobenzyl)-4-piperidone oxime is prepared from 1-(2-chlorobenzyl)-4-piperidone and hydroxylamine hydrochloride essentially as described above in Example 38, Scheme C, step b.

Sources & evidence

ORD record: ord-aa58cfe132614d8f9dd8c3295face5eb
Source dataset: uspto-grants-2002_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06479487B1

Reaction notes

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