4-Piperidone → HCID 11959579, compound

HRID 1017337Notes

Reaction equation

HRID 1017337 reaction equation
[NH:1]1[CH2:6][CH2:5][C:4](=[O:7])[CH2:3][CH2:2]1.Cl[CH2:9][C:10]1[CH:15]=[CH:14][C:13]([C:16]([F:19])([F:18])[F:17])=[CH:12][CH:11]=1>>[F:17][C:16]([F:18])([F:19])[C:13]1[CH:14]=[CH:15][C:10]([CH2:9][N:1]2[CH2:6][CH2:5][C:4](=[O:7])[CH2:3][CH2:2]2)=[CH:11][CH:12]=1

Participants

3

Reactant 2

HCID 337214-PiperidoneHCID 123096p-Trifluoromethylbenzyl chloride

Product 1

HCID 11959579HCID 11959579, compound

Procedure

1-(4-Trifluoromethylbenzyl)-4-piperidone is prepared from 4-piperidone and α′-chloro-α,α,α-trifluoro-p-xylene essentially as described above in Example 38, Scheme C, step a.

Sources & evidence

ORD record
ord-3a219e0af9ca48afb4269e1cc3195d14
Source dataset
uspto-grants-2002_11
Patent number
US06479487B1

Reaction notes

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