Picolyl chloride hydrochloride → 1-Pyridin-2-ylmethylpiperidin-4-one

HRID 1017348Notes

Reaction equation

[NH:1]1[CH2:6][CH2:5][C:4](=[O:7])[CH2:3][CH2:2]1.Cl.[N:9]1[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=1[CH2:15]Cl>>[N:9]1[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=1[CH2:15][N:1]1[CH2:6][CH2:5][C:4](=[O:7])[CH2:3][CH2:2]1

Participants

Reactant 2

HCID 23392Picolyl chloride hydrochloride

HCID 337214-Piperidone

Product 1

HCID 112292581-Pyridin-2-ylmethylpiperidin-4-one

Procedure

1-(2-Pyridinylmethyl)-4-piperidone is prepared from 4-piperidone and 2-picolyl chloride hydrochloride essentially as described above in Example 38, Scheme C, step a.

Sources & evidence

ORD record: ord-f4cc269aaa2e497eaee374d7b0472adf
Source dataset: uspto-grants-2002_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06479487B1

Reaction notes

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