Piperidine → 2-Amino-5-(piperidin-1-yl)benzamide

HRID 1017513Notes

Reaction equation

[NH2:1][C:2]1[CH:10]=[CH:9][C:8]([N:11]([CH3:13])[CH3:12])=[CH:7][C:3]=1[C:4]([NH2:6])=[O:5].N1CC[CH2:17][CH2:16][CH2:15]1>>[NH2:1][C:2]1[CH:10]=[CH:9][C:8]([N:11]2[CH2:13][CH2:17][CH2:16][CH2:15][CH2:12]2)=[CH:7][C:3]=1[C:4]([NH2:6])=[O:5]

Participants

Reactant 2

HCID 8082Piperidine

HCID 127157972-Amino-5-(dimethylamino)benzamide

Product 1

HCID 107276062-Amino-5-(piperidin-1-yl)benzamide

Procedure

According to the preparation of 25, piperidine was used to afford 27 (0.8 g) as brown powder; MS m/z 219 (M+).

Sources & evidence

ORD record: ord-e3d76d2a5d9148369a2e3aa2fccaac04
Source dataset: uspto-grants-2002_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06479499B1

Reaction notes

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