2-Methoxybenzaldehyde → 2-(2-methoxyphenyl)-3H-quinazolin-4-one

HRID 1017517Notes

Reaction equation

HRID 1017517 reaction equation
[C:1]1([C:7]2[NH:16][C:15](=[O:17])[C:14]3[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=3)[N:8]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH3:18][O:19]C1C=CC=CC=1C=O>>[CH3:18][O:19][C:6]1[CH:5]=[CH:4][CH:3]=[CH:2][C:1]=1[C:7]1[NH:16][C:15](=[O:17])[C:14]2[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=2)[N:8]=1

Participants

3

Reactant 2

HCID 86582-MethoxybenzaldehydeHCID 1354004562-Phenyl-4(3H)-Quinazolinone

Product 1

HCID 1354360052-(2-methoxyphenyl)-3H-quinazolin-4-oneYield 89.1%

Procedure

According to the preparation of 41, 2-methoxybenzaldehyde (33) (1.0 g, 7.3 mmol) was used to afford 42 (1.6 g, 89.1%) as pale yellow needles.

Sources & evidence

ORD record
ord-7af50da8f8964fd581bc48c4d25cb25d
Source dataset
uspto-grants-2002_11
Patent number
US06479499B1

Reaction notes

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