HCID 54257403, compound → HCID 9909040, compound

HRID 1017552Notes

Reaction equation

HRID 1017552 reaction equation
C([O:8][C:9](=[O:35])[CH2:10][CH:11]([S:19]([N:22]1[CH2:27][CH2:26][CH:25]([CH2:28][C:29]2[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=2)[CH2:24][CH2:23]1)(=[O:21])=[O:20])[CH2:12][C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)C1C=CC=CC=1>CCOC(C)=O.[Pd]>[CH2:28]([CH:25]1[CH2:26][CH2:27][N:22]([S:19]([CH:11]([CH2:12][C:13]2[CH:14]=[CH:15][CH:16]=[CH:17][CH:18]=2)[CH2:10][C:9]([OH:35])=[O:8])(=[O:21])=[O:20])[CH2:23][CH2:24]1)[C:29]1[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=1

Participants

4

Reactant 1

HCID 54257403HCID 54257403, compound

Product 1

HCID 9909040HCID 9909040, compoundYield 99.6%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 8857Ethyl AcetateSolvent

Procedure

The product from Step E (360 mg, 0.73 mmol) was taken up in EtOAc (10 mL) with stirring under a blanket of argon. 10% palladium on charcoal (130 mg) was added. The resulting suspension was hydrogenated in a PARR apparatus at room temperature overnight. The system was purged with argon and the catalyst removed by filtration. The filtrate was evaporated under reduced pressure to give the desired product as a gum (292mg, Quant). 1H-NMR δ(MeOD) 7.24-7.10 (10H, m), 3.89 (1H, m), 3.69 (2H, m), 3.25 (1H, dd, J=4.8, 17.1 Hz), 2.81-2.64 (4H, m), 2.53 (2H, d, J=6.7 Hz), 2.45 (1H, dd, J=4.8, 17.1 Hz), 1.61 (3H, m) and 1.28 (2H, m). 13C-NMR δ(MeOD) 174.3, 141.7, 138.8, 130.8, 130.6, 130.2, 129.7, 128.4, 127.4, 61.0, 47.6, 44.2, 39.2, 36.6, 34.8, 33.7. ESMS=(M+1) 402.2, (M−1) 400.0.

Workup

  1. customThe system was purged with argon
  2. customthe catalyst removed by filtration
  3. customThe filtrate was evaporated under reduced pressure

Sources & evidence

ORD record
ord-98a059af2ca34587a8a8154bcca6c3df
Source dataset
uspto-grants-2002_11
Patent number
US06479502B1

Reaction notes

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