HuagongsheHuagongshe Chemistry Print Report · For research reference only
Iodobenzene → HCID 18403571, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Iodobenzene | HCID 11575 | — |
| Reactant | Borate | HCID 26574 | — |
| Reactant | Bis(pinacolato)diborane | HCID 2733548 | — |
| Reactant | HCID 18403552 | HCID 18403552 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Catalyst | Bis(cyclopenta-1,4-dien-1-yl(diphenyl)phosphane);dichloropalladium;iron(2+) | HCID 178418228 | — |
| Product | HCID 18403571 | HCID 18403571 | — |
Reaction Steps
Treatment of an iodobenzene of formula 11 with bis(pinacolato)diborane in the presence of a palladium catalyst such as PdCl2(dppf), followed by coupling of the resulting borate with a 4-bromo-3-(1-methylindol-3-ylmethyl)-1-methyl-pyrrole-2,5-dione 12 under Suzuki reaction conditions provides a 4-phenyl-3-(1-methylindol-3-ylmethyl)-1-methylpyrrole-2,5-dione 13. Compounds of formula 12 can be prepared by methods well known in the art. For example, 4-bromo-3-(1-methylindol-3-yl)-1-methylpyrrole-2,5-dione can be prepared by method described in Brenner, M. et al., Tet. Lett., 44, 2887, (1988).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06479490B2 |
| Source dataset | uspto-grants-2002_11 |
| ORD ID | ord-ae4fd35189784b959f835000f0a235e8 |
| Source note | uspto-grants-2002_11 |