反应详情

A solution of 1-methylindole-3-glyoxylyl chloride in dichloromethane (350 mL) was added to a solution of 3-nitrophenylacetic acid (8.5 g, 0.093 mL) and triethylamine (13 mL, 93 mmol) in dichloromethane (350 mL) at 0° C. The reaction mixture was then stirred at room temperature overnight and then concentrate under reduced pressure. The crude product was purified on a silica gel column with 6:1 hexane/ethyl acetate to afford 3-(1-methylindol-3-yl)-4-(3-nitrophenyl)furan-2,5-dione (9 g, 55%).

1. concentrationconcentrate under reduced pressure
2. customThe crude product was purified on a silica gel column with 6:1 hexane/ethyl acetate