Benzyloxycarbonyl-L-proline → HCID 86758595, compound

HRID 1017690Notes

Reaction equation

HRID 1017690 reaction equation
[C:1]1([CH2:7][O:8][C:9]([N:11]2[CH2:18][CH2:17][CH2:16][C@H:12]2[C:13]([OH:15])=O)=[O:10])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[NH2:19][CH2:20][CH:21]1[CH2:26][CH2:25][N:24]([C:27]([O:29][C:30]([CH3:33])([CH3:32])[CH3:31])=[O:28])[CH2:23][CH2:22]1>>[C:1]1([CH2:7][O:8][C:9]([N:11]2[CH2:18][CH2:17][CH2:16][C@H:12]2[C:13]([NH:19][CH2:20][CH:21]2[CH2:26][CH2:25][N:24]([C:27]([O:29][C:30]([CH3:33])([CH3:32])[CH3:31])=[O:28])[CH2:23][CH2:22]2)=[O:15])=[O:10])[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

Participants

3

Reactant 2

HCID 101987Benzyloxycarbonyl-L-prolineHCID 7368171-Boc-4-(aminomethyl)piperidine

Product 1

HCID 86758595HCID 86758595, compound

Procedure

Working analogously to Example 1, starting from N-[(phenyl-methoxy)carbonyl]-L-proline and 4-(aminomethyl)-1-piperidinecarboxylic acid, 1,1-dimethylethyl ester, the expected product is obtained in the form of a creamy white solid (Yield=99%).

Sources & evidence

ORD record
ord-3665cfa0a8c54fb988c35a106f236c70
Source dataset
uspto-grants-2002_11
Patent number
US06479515B1

Reaction notes

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