Methanesulfonic Acid → HCID 178477924, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 4-(2-chlorophenyl)-1-(1H-imidazol-4-yl)-butan-1-ol hydrochloride (1.0 g) and methanesulfonic acid (15 ml) is heated at 100° C. for 2 hours. The cooled reaction mixture is poured into water and is made alkaline with sodium hydroxide solution. The product is extracted into ethyl acetate which is washed with water, dried with sodium sulfate and evaporated under reduced pressure. The crude product is recrystallized from ethyl acetate. The yield is 0.4 g, m.p. 165-169° C.

Provenance & Evidence