反应详情

温度

100 °C

A mixture of 4-(2-chlorophenyl)-1-(1H-imidazol-4-yl)-butan-1-ol hydrochloride (1.0 g) and methanesulfonic acid (15 ml) is heated at 100° C. for 2 hours. The cooled reaction mixture is poured into water and is made alkaline with sodium hydroxide solution. The product is extracted into ethyl acetate which is washed with water, dried with sodium sulfate and evaporated under reduced pressure. The crude product is recrystallized from ethyl acetate. The yield is 0.4 g, m.p. 165-169° C.

1. customThe cooled reaction mixture
2. extractionThe product is extracted into ethyl acetate which
3. washis washed with water
4. dry with materialdried with sodium sulfate
5. customevaporated under reduced pressure
6. customThe crude product is recrystallized from ethyl acetate