反应详情

温度

92.5 °C

A mixture of 2,3-dimethylanisole (2.0 g), 3-(3-benzyl-3H-imidazol-4-yl)-acrylic acid (3.4 g) and methanesulfonic acid (60 ml) is heated at 90-95° C. for 45 minutes.The cooled reaction mixture is poured into water and is made alkaline with sodium hydroxide solution. The product is extracted into ethyl acetate which is washed with water, dried with sodium sulfate and evaporated in reduced pressure. The crude product is purified by flash chromatography by eluting with methylene chloride-methanol solution. The yield is 1.1 g.

1. customThe cooled reaction mixture
2. extractionThe product is extracted into ethyl acetate which
3. washis washed with water
4. dry with materialdried with sodium sulfate
5. customevaporated in reduced pressure
6. customThe crude product is purified by flash chromatography
7. washby eluting with methylene chloride-methanol solution