反应详情

温度

37.5 °C

3-(1H-Imidazol-4-yl)-5-methoxy-6,7-dimethylindan-1-one (0.53 g) is dissolved in ethanol (30 ml) and 0.3 g of sodium borohydride is added. The mixture is stirred at 35-40° C. for 7 hours. About 20 ml of ethanol is then distilled off and 30 ml of water is added. The solution is extracted with ethyl acetate. The combined ethyl acetate extracts are washed with water, dried with sodium sulfate, and evaporated under reduced pressure. The product is the mixture of cis- and trans-isomers (about 85:15). Crystallization of the product from ethyl acetate gives a cis-isomer, m.p. 184-189° C.

1. distillationAbout 20 ml of ethanol is then distilled off
2. addition30 ml of water is added
3. extractionThe solution is extracted with ethyl acetate
4. washThe combined ethyl acetate extracts are washed with water
5. dry with materialdried with sodium sulfate
6. customevaporated under reduced pressure
7. additionthe mixture of cis- and trans-isomers (about 85:15)
8. customCrystallization of the product from ethyl acetate
9. customgives a cis-isomer, m.p. 184-189° C.