反应详情

3-(1H-Imidazol-4-yl)-5-methoxy-6,7-dimethylindan-1-ol (0.29 g) is dissolved in the mixture of ethanol (30 ml) and concentrated hydrochloric acid (0.2 ml). The solution is hydrogenated at 50-55° C. with 10% palladium on carbon as catalyst until no more hydrogen is consumed. The mixture is filtered and the filtrate is evaporated to dryness. The residue is crystallized from the mixture of ethyl acetate and ethanol. M.p. of the hydrochloride salt is 174-177° C.

1. customis consumed
2. filtrationThe mixture is filtered
3. customthe filtrate is evaporated to dryness
4. customThe residue is crystallized from the mixture of ethyl acetate and ethanol
5. customis 174-177° C.