HCID 178418361, compound → 5-(2,3-dihydro-1H-inden-1-yl)-1H-imidazole

HRID 1017753Notes

Reaction equation

HRID 1017753 reaction equation
Cl.[C:2]1([C:11]2[N:12]=[CH:13][NH:14][CH:15]=2)[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH2:4][CH:3]=1.[H][H]>C(O)C.[Pd]>[CH:2]1([C:11]2[N:12]=[CH:13][NH:14][CH:15]=2)[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH2:4][CH2:3]1

Participants

5

Reactant 2

HCID 178418361HCID 178418361, compoundHCID 178419845HCID 178419845, compound

Product 1

HCID 1784198835-(2,3-dihydro-1H-inden-1-yl)-1H-imidazole

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

4-(3H-Inden-1-yl)-1H-imidazole hydrochloride (80 mg) is dissolved in ethanol (6 ml). The reaction solution is hydrogenated at 40-50° C. with 10% palladium on carbon as catalyst until no more hydrogen is consumed. Work-up of the reaction mixture gives the crude product which is purified by flash chromatography using methylene chloride-methanol as eluent.

Workup

  1. customis consumed

Sources & evidence

ORD record
ord-4e205765707745dd9c4185c1e247a168
Source dataset
uspto-grants-2002_11
Patent number
US06479530B2

Reaction notes

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