反应详情

温度

50 °C

To a solution of 40 mg of 1-(S)-(1-(R)-(3,5-bis(trifluoromethyl)-phenyl)ethoxy)-2-(S)-(4-fluorophenyl)-3-(R)-(methylamino)cyclopentane from Example 15 in 1 mL of acetonitrile was added 0.011 mL of methyl 3-bromo-proprionate and 0.046 mL of DIPEA. The reaction was heated at 50° C. for 24 hours, then an additional 0.011 mL of methyl 3-bromoproprionate and 0.030 mL of DIPEA were added and heating continued at 80° C. for 60 hours. The reaction was evaporated under a stream of nitrogen and the residue purified by prep TLC (5% methanol in methylene chloride) to give 39 mg of title compound. Mass spec (ESI): 536 (M+1).

1. temperatureheating
2. customThe reaction was evaporated under a stream of nitrogen
3. customthe residue purified by prep TLC (5% methanol in methylene chloride)