HCID 18404481, compound → HCID 18404459, compound

HRID 1017773Notes

Reaction equation

HRID 1017773 reaction equation
C(OC([N:11]1[CH2:16][CH2:15][CH:14]([C:17]([NH:19][S:20]([CH3:23])(=[O:22])=[O:21])=[O:18])[CH2:13][CH2:12]1)=O)C1C=CC=CC=1>CO.[Pd]>[CH3:23][S:20]([NH:19][C:17]([CH:14]1[CH2:13][CH2:12][NH:11][CH2:16][CH2:15]1)=[O:18])(=[O:21])=[O:22]

Participants

4

Reactant 1

HCID 18404481HCID 18404481, compound

Product 1

HCID 18404459HCID 18404459, compoundYield 41%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

The 197 mg of the product from Step A was taken up in 5 mL of methanol and hydrogenated at 40 psi over 60 mg of 10% Pd/C for 16 hours. The catalyst was removed by filtration and the solvent was removed in vacuo to afford 49 mg of title compound.

Workup

  1. customThe catalyst was removed by filtration
  2. customthe solvent was removed in vacuo

Sources & evidence

ORD record
ord-37197ac7437149aca72f8b3d3b6edaf2
Source dataset
uspto-grants-2002_11
Patent number
US06479518B2

Reaction notes

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