Pyridine → 3-Amino-4-iodo-benzophenone
Reaction equation
[I:1][C:2]1[CH:15]=[CH:14][C:5]([C:6]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)=[O:7])=[CH:4][C:3]=1[N+:16]([O-])=O.S(S([O-])=O)([O-])=O.[Na+].[Na+].N1C=CC=CC=1>O>[NH2:16][C:3]1[CH:4]=[C:5]([CH:14]=[CH:15][C:2]=1[I:1])[C:6]([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)=[O:7]Participants
5
Reactant 3
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 40 °C
Procedure
A mixture of 5.0 g (14 mmol) of 4-iodo-3-nitro-benzophenone, 7.5 g (42 mmol) of sodium dithionite, 40 ml of pyridine and 15 ml of water is heated to 40° C. for 2 hours. Then the mixture is concentrated in vacuo, combined with ice water and extracted with ethyl acetate. The organic phase is dried with sodium sulphate and the solvent is distilled off in vacuo.
Workup
- concentrationThen the mixture is concentrated in vacuo
- extractionextracted with ethyl acetate
- dry with materialThe organic phase is dried with sodium sulphate
- distillationthe solvent is distilled off in vacuo
Sources & evidence
- ORD record
- ord-3b9cd23a6a8f4bd8aaf0982c10cd3699
- Source dataset
- uspto-grants-2002_11
- Patent number
- US06479524B1
Reaction notes
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