反应详情

25.0 g (71.8 mmol) of benzyltrimethylammonium dichloriodate and 12.8 g (92.5 mmol) of potassium carbonate are added to a solution of 8.8 ml of (70.8 mmol) of 2,5-dimethylaniline in 250 ml of methanol and 600 ml of dichloromethane and stirred for 1 hour at ambient temperature. Then the inorganic salts are suction filtered and the solvent is distilled off. The residue is combined with a solution of 13.5 g (70.8 mmol) of sodium pyrosulphite in 640 ml of water and extracted with ether. The combined organic extracts are dried over sodium sulphate and evaporated down. The crude product is triturated with petroleum ether, suction filtered and dried.

1. filtrationfiltered
2. distillationthe solvent is distilled off
3. extractionextracted with ether
4. dry with materialThe combined organic extracts are dried over sodium sulphate
5. customevaporated down
6. customThe crude product is triturated with petroleum ether, suction
7. filtrationfiltered
8. customdried