Chloroform → 1-t-Butyl-3,3-dipropyl-5,5-dimethyl-piperazin-2-on

HRID 1017970Notes

Reaction equation

[CH3:1][C:2]([NH2:10])([CH3:9])[CH2:3][NH:4][C:5]([CH3:8])([CH3:7])[CH3:6].[CH2:11]([C:14]([CH2:16][CH2:17][CH3:18])=O)[CH2:12][CH3:13].[OH-:19].[Na+].[CH:21](Cl)(Cl)Cl>>[C:5]([N:4]1[CH2:3][C:2]([CH3:9])([CH3:1])[NH:10][C:14]([CH2:16][CH2:17][CH3:18])([CH2:11][CH2:12][CH3:13])[C:21]1=[O:19])([CH3:8])([CH3:7])[CH3:6]

Participants

Reactant 4

HCID 6212Chloroform

HCID 14798Sodium Hydroxide

HCID 312464-Heptanone

HCID 125809891,2-Propanediamine, N1-(1,1-dimethylethyl)-2-methyl-

Product 1

HCID 187605551-t-Butyl-3,3-dipropyl-5,5-dimethyl-piperazin-2-on

Procedure

In analogy to Example B21, 1,1-dimethyl-2-t-butylaminoethylamin, dipropylketon, chloroform and NaOH are reacted to give the title compound as a yellow oil.

Sources & evidence

ORD record: ord-3256504f99da4a47bd929060e482edb6
Source dataset: uspto-grants-2002_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06479608B1

Reaction notes

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