Chloroform → 1-t-Butyl-3-isobutyl-3,5,5-trimethyl-piperazin-2-on

HRID 1017974Notes

Reaction equation

[CH3:1][C:2]([NH2:10])([CH3:9])[CH2:3][NH:4][C:5]([CH3:8])([CH3:7])[CH3:6].[CH3:11][C:12]([CH2:14][CH:15]([CH3:17])[CH3:16])=O.[OH-:18].[Na+].[CH:20](Cl)(Cl)Cl>>[C:5]([N:4]1[CH2:3][C:2]([CH3:9])([CH3:1])[NH:10][C:12]([CH2:14][CH:15]([CH3:17])[CH3:16])([CH3:20])[C:11]1=[O:18])([CH3:8])([CH3:7])[CH3:6]

Participants

Reactant 4

HCID 6212Chloroform

HCID 7909Methyl Isobutyl Ketone

HCID 14798Sodium Hydroxide

HCID 125809891,2-Propanediamine, N1-(1,1-dimethylethyl)-2-methyl-

Product 1

HCID 187604761-t-Butyl-3-isobutyl-3,5,5-trimethyl-piperazin-2-on

Procedure

In analogy to Example B21, 1,1-dimethyl-2-t-butylaminoethylamin, methylisobutylketon, chloroform and NaOH are reacted to give the title compound as a colorless oil.

Sources & evidence

ORD record: ord-d4c282c1756f43cd9e95c1549fe2e94a
Source dataset: uspto-grants-2002_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06479608B1

Reaction notes

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