反应详情

A mixture of 5-nitro-2-pyridinecarbaldehyde (2.85 g prepared according the procedure described in J. Med. Chem. 1992, 35, 3675) and (carbethoxymethylene)triphenylphosphorane (6.0 g) in dry toluene (120 ml) under nitrogen was stirred and heated at reflux for 6 hours. After standing at room temperature overnight the reaction mixture was evaporated. The residue was subjected to flash chromatography on silica gel eluting with dichloromethane to give the title compound (0.8 g) as a yellow solid.

1. customprepared
2. temperatureheated
3. temperatureat reflux for 6 hours
4. customthe reaction mixture was evaporated