HuagongsheHuagongshe Chemistry Print Report · For research reference only
Formaldehyde → 4-Amino-7-(2-deoxy-beta-d-erythropentofuranosyl)-5-morpholinomethyl-7h-pyrrolo-[2,3-d]pyrimidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Formaldehyde | HCID 712 | — |
| Reactant | Tubercidin | HCID 6245 | — |
| Reactant | Morpholine | HCID 8083 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 4-Amino-7-(2-deoxy-beta-d-erythropentofuranosyl)-5-morpholinomethyl-7h-pyrrolo-[2,3-d]pyrimidine | HCID 102095194 | — |
Reaction Steps
can be prepared by using the Mannich reaction. The 5-morpholinomethyl derivative (Watanabe et al., Nucleosides & Nucleotides, 1(2), 191-203, 1982) is obtained by heating tubercidin together with paraformaldehyde and morpholine in DMF. The 5-morpholine derivative (33) is obtained in accordance with the silylation and deoxygenation described in Ex. 33.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06479651B1 |
| Source dataset | uspto-grants-2002_11 |
| ORD ID | ord-35be0d7efa2d4070b8e00480b4d054bc |
| Source note | uspto-grants-2002_11 |