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HRID1018036

反应详情

EQUATION

反应方程式

HRID 1018036 的结构方程式

REACTANTS

反应物

3
结构：C=O
HCID712

Formaldehyde

CH2O

结构：Nc1ncnc2c1ccn2[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O
HCID6245

Tubercidin

C11H14N4O4

结构：C1COCCN1
HCID8083

Morpholine

C4H9NO

PRODUCTS

生成物

1
结构：Nc1ncnc2c1c(CN1CCOCC1)cn2[C@H]1C[C@H](O)[C@@H](CO)O1
HCID102095194

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CN(C)C=O
溶剂HCID6228

N,N-Dimethylformamide

C3H7NO

PROCEDURE

实验过程

can be prepared by using the Mannich reaction. The 5-morpholinomethyl derivative (Watanabe et al., Nucleosides & Nucleotides, 1(2), 191-203, 1982) is obtained by heating tubercidin together with paraformaldehyde and morpholine in DMF. The 5-morpholine derivative (33) is obtained in accordance with the silylation and deoxygenation described in Ex. 33.

WORKUP

后处理

  1. customcan be prepared
  2. customthe Mannich reaction