反应详情

Dissolve 2-[4-(4-chloro-butyryl)-phenyl]-2-methyl-propionic acid (6.2 g, 23.1 mmol) in hot methanolic solution of anhydrous hydrogen chloride (42 mL of a methanol containing 3.2 g of anhydrous hydrogen chloride). Reflux for 42 minutes, evaporate the solvent in vacuo, dissolve the residue in methylene chloride and wash with water. Dry (MgSO4), filter through silica gel, washing the gel with methylene chloride. Combine the organic washings and evaporate the solvent in vacuo to give the title compound as a clear oil (6.21 g, 94%).

1. temperatureReflux for 42 minutes
2. customevaporate the solvent in vacuo
3. dissolutiondissolve the residue in methylene chloride
4. washwash with water
5. dry with materialDry (MgSO4)
6. filtrationfilter through silica gel
7. washwashing the gel with methylene chloride
8. customevaporate the solvent in vacuo