1,4-Dioxane → [1-(2-Chloro-6,7-dihydrothieno[3,2-d]pyrimidin-4-ylamino)-cyclopropyl]-methanol

HRID 101818Notes

Reaction equation

HRID 101818 reaction equation
[CH:12]([N:13]([CH:14]([CH3:15])[CH3:16])[CH2:17][CH3:18])([CH3:19])[CH3:20].[Cl:1][c:2]1[n:3][c:4]([Cl:11])[c:5]2[c:6]([n:7]1)[CH2:8][CH2:9][S:10]2.[NH2:21][C:22]1([CH2:25][OH:26])[CH2:23][CH2:24]1.[O:27]1[CH2:28][CH2:29][O:30][CH2:31][CH2:32]1>>[Cl:1][c:2]1[n:3][c:4]([NH:21][C:22]2([CH2:25][OH:26])[CH2:23][CH2:24]2)[c:5]2[c:6]([n:7]1)[CH2:8][CH2:9][S:10]2

Participants

5

Reactant 4

HCID 312751,4-DioxaneHCID 81531DiisopropylethylamineHCID 14146220(1-Aminocyclopropyl)methanolHCID 457899672,4-Dichloro-6,7-dihydrothieno[3,2-d]pyrimidine

Product 1

HCID 59708441[1-(2-Chloro-6,7-dihydrothieno[3,2-d]pyrimidin-4-ylamino)-cyclopropyl]-methanol

Sources & evidence

ORD record
ord-61aee9aed09c4e5ab941a6a4c2acc2ba
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (2/10)

Reaction notes

Loading…