Ammonium Hydroxide → HCID 9899303, compound

HRID 1018259Notes

Reaction equation

HRID 1018259 reaction equation
Cl.CO[C:4](=[O:18])[C@H:5]([CH2:7][C:8]1[C:16]2[C:11](=[CH:12][CH:13]=[C:14]([OH:17])[CH:15]=2)[NH:10][CH:9]=1)[NH2:6].[OH-].[NH4+:20]>>[OH:17][C:14]1[CH:15]=[C:16]2[C:11]([NH:10][CH:9]=[C:8]2[CH2:7][C@@H:5]([C:4]([NH2:20])=[O:18])[NH2:6])=[CH:12][CH:13]=1

Participants

3

Reactant 2

HCID 14923Ammonium HydroxideHCID 24802218methyl (2S)-2-amino-3-(5-hydroxy-1H-indol-3-yl)propanoate hydrochloride

Product 1

HCID 9899303HCID 9899303, compound

Procedure

(S)-5-Hydroxytryptophan methyl ester hydrochloride (0.247 g, 0.91 mmol) was stirred overnight at room temperature in ammonium hydroxide (10 mL). After removal of volatiles under vacuum, the title compound of example 44 was obtained as a dark solid.

Workup

  1. customAfter removal of volatiles under vacuum

Sources & evidence

ORD record
ord-a6638a3dc1e34de09f15bc33e5dd0439
Source dataset
uspto-grants-2002_11
Patent number
US06479508B1

Reaction notes

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