Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Water → 3-[(5-Cycloheptylmethyl-2-o-tolyl-1H-imidazole-4-carbonyl)-amino]-benzoic Acid
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | N-Methyl-D-glucamine | HCID 8567 | — |
| 반응물 | 2-Methylbenzaldehyde | HCID 10722 | — |
| 반응물 | Dibenzyl 5-aminoisophthalate | HCID 7023592 | — |
| 반응물 | Benzyl 3-aminobenzoate | HCID 15428374 | — |
| 반응물 | 1,4-Dioxane--water (1/1) | HCID 21886435 | — |
| 생성물 | 3-[(5-Cycloheptylmethyl-2-o-tolyl-1H-imidazole-4-carbonyl)-amino]-benzoic Acid | HCID 18405569 | — |
반응 단계
The title compound was prepared according to the procedure of Example 20, with the modification that o-tolualdehyde was used instead of 2-naphthaldehyde in step b, and 3-amino-benzoic acid benzyl ester replaced 5-amino-isophthalic acid dibenzyl ester in step d. 1H NMR (300 MHz, d6-DMSO) 13.00 (1H, br s), 12.52 (1H, br s), 9.78 (1H, s), 8.51 (1H, s), 7.93 (1H, m), 7.60 (2H, m), 7.41 (1H, t), 7.32 (3H, m), 2.93 (2H, d), 2.54 (3H, s), 2.00 (1H, m), 1.66-1.22 (12H, m). The acid was converted to the N-methyl-D-glucamine salt and lyophilised from water/dioxan. Found: C, 60.05; H, 7.70; N, 8.46%. C33H46N4O8.1.9 mols H2O requires: C, 60.03; H, 7.59; N, 8.49%.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06479531B1 |
| 출처 데이터셋 | uspto-grants-2002_11 |
| ORD ID | ord-fd134e0423804823aa9d45b14819109b |
| 출처 메모 | uspto-grants-2002_11 |