1-(2,2-Dimethoxyethyl)-piperidin-2-one → 1-Piperidineacetaldehyde, 2-oxo-

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Reaction Steps

A mixture of 1-(2,2-dimethoxyethyl)-piperidin-2-one (1.06 g, 5.67 mmole) in 5% aqueous tetrahydrofuran (20 mL) was heated under reflux for 1 hour. The mixture was dried with anhydrous magnesium sulfate, filtered, and concentrated to give (2-oxo-piperidin-1-yl)-acetaldehyde (0.69 g) as a pale yellow oil.

Provenance & Evidence