1-(2,2-Dimethoxyethyl)-piperidin-2-one → 1-Piperidineacetaldehyde, 2-oxo-

HRID 10184Notes

Reaction equation

HRID 10184 reaction equation
C[O:2][CH:3](OC)[CH2:4][N:5]1[CH2:10][CH2:9][CH2:8][CH2:7][C:6]1=[O:11]>O1CCCC1>[O:11]=[C:6]1[CH2:7][CH2:8][CH2:9][CH2:10][N:5]1[CH2:4][CH:3]=[O:2]

Participants

3

Reactant 1

HCID 219785091-(2,2-Dimethoxyethyl)-piperidin-2-one

Product 1

HCID 206097901-Piperidineacetaldehyde, 2-oxo-Yield 86.2%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

A mixture of 1-(2,2-dimethoxyethyl)-piperidin-2-one (1.06 g, 5.67 mmole) in 5% aqueous tetrahydrofuran (20 mL) was heated under reflux for 1 hour. The mixture was dried with anhydrous magnesium sulfate, filtered, and concentrated to give (2-oxo-piperidin-1-yl)-acetaldehyde (0.69 g) as a pale yellow oil.

Workup

  1. temperaturewas heated
  2. temperatureunder reflux for 1 hour
  3. dry with materialThe mixture was dried with anhydrous magnesium sulfate
  4. filtrationfiltered
  5. concentrationconcentrated

Sources & evidence

ORD record
ord-6622273b486740e4aa60235c3f1f6212
Source dataset
uspto-grants-2006_08
Patent number
US07094778B2

Reaction notes

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