8-(3,5-Bis-trifluoromethyl-benzoyl)-1-phenyl-1,3,8-triaza-spiro[4.5]decan-4-one → HCID 18401704, compound

HRID 1018554Notes

Reaction equation

HRID 1018554 reaction equation
[F:1][C:2]([F:33])([F:32])[C:3]1[CH:4]=[C:5]([CH:25]=[C:26]([C:28]([F:31])([F:30])[F:29])[CH:27]=1)[C:6]([N:8]1[CH2:24][CH2:23][C:11]2([N:15]([C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=3)[CH2:14][NH:13][C:12]2=[O:22])[CH2:10][CH2:9]1)=[O:7]>BrCCCO[Si](C(C)(C)C)(C)C.COCCOC>[F:33][C:2]([F:1])([F:32])[C:3]1[CH:4]=[C:5]([CH:25]=[C:26]([C:28]([F:31])([F:30])[F:29])[CH:27]=1)[C:6]([N:8]1[CH2:9][CH2:10][C:11]2([N:15]([C:16]3[CH:17]=[CH:18][CH:19]=[CH:20][CH:21]=3)[CH2:14][N:13]([CH2:4][CH2:5][CH2:6][OH:7])[C:12]2=[O:22])[CH2:23][CH2:24]1)=[O:7]

Participants

4

Reactant 1

HCID 184017258-(3,5-Bis-trifluoromethyl-benzoyl)-1-phenyl-1,3,8-triaza-spiro[4.5]decan-4-one

Product 1

HCID 18401704HCID 18401704, compound

Reagents, catalysts & solvents 2

HCID 80711,2-DimethoxyethaneSolventHCID 607486(3-Bromopropoxy)(tert-butyl)dimethylsilaneSolvent

Procedure

The title compound, MS: m/e=530.2 (M+H+), was prepared in accordance with the general method of example 4 from 8-(3,5-bis-trifluoromethyl-benzoyl)-1-phenyl-1,3,8-triaza-spiro[4.5]decan-4-one and (3-bromopropoxy)-tert.-butyldimethylsilane in 1,2-dimethoxyethane as solvent. HCl in ethanol (3% conc.) cleaved the intermediate TBDMS-ether.

Sources & evidence

ORD record
ord-02511e318b9b40588209cb2a43dee91a
Source dataset
uspto-grants-2002_11
Patent number
US06482829B2

Reaction notes

Loading…