HuagongsheHuagongshe Chemistry Print Report · For research reference only
8-(3,5-Bis-trifluoromethyl-benzoyl)-1-phenyl-1,3,8-triaza-spiro[4.5]decan-4-one → HCID 18401704, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 8-(3,5-Bis-trifluoromethyl-benzoyl)-1-phenyl-1,3,8-triaza-spiro[4.5]decan-4-one | HCID 18401725 | — |
| Solvent | 1,2-Dimethoxyethane | HCID 8071 | — |
| Solvent | (3-Bromopropoxy)(tert-butyl)dimethylsilane | HCID 607486 | — |
| Product | HCID 18401704 | HCID 18401704 | — |
Reaction Steps
The title compound, MS: m/e=530.2 (M+H+), was prepared in accordance with the general method of example 4 from 8-(3,5-bis-trifluoromethyl-benzoyl)-1-phenyl-1,3,8-triaza-spiro[4.5]decan-4-one and (3-bromopropoxy)-tert.-butyldimethylsilane in 1,2-dimethoxyethane as solvent. HCl in ethanol (3% conc.) cleaved the intermediate TBDMS-ether.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06482829B2 |
| Source dataset | uspto-grants-2002_11 |
| ORD ID | ord-02511e318b9b40588209cb2a43dee91a |
| Source note | uspto-grants-2002_11 |