1-Methylpiperazine → HCID 18401716, compound

HRID 1018563Notes

Reaction equation

[F:1][C:2]([F:36])([F:35])[C:3]1[CH:4]=[C:5]([CH:28]=[C:29]([C:31]([F:34])([F:33])[F:32])[CH:30]=1)[C:6]([N:8]1[CH2:27][CH2:26][C:11]2([N:15]([C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=3)[CH2:14][N:13]([CH2:22][CH2:23]O)[C:12]2=[O:25])[CH2:10][CH2:9]1)=[O:7].[CH3:37][N:38]1[CH2:43][CH2:42][NH:41][CH2:40][CH2:39]1>>[F:36][C:2]([F:1])([F:35])[C:3]1[CH:4]=[C:5]([CH:28]=[C:29]([C:31]([F:32])([F:34])[F:33])[CH:30]=1)[C:6]([N:8]1[CH2:27][CH2:26][C:11]2([N:15]([C:16]3[CH:17]=[CH:18][CH:19]=[CH:20][CH:21]=3)[CH2:14][N:13]([CH2:22][CH2:23][N:41]3[CH2:42][CH2:43][N:38]([CH3:37])[CH2:39][CH2:40]3)[C:12]2=[O:25])[CH2:10][CH2:9]1)=[O:7]

Participants

Reactant 2

HCID 531671-Methylpiperazine

HCID 18401628HCID 18401628, compound

Product 1

HCID 18401716HCID 18401716, compound

Procedure

The title compound, MS: m/e=598.1 (M+H+), was prepared in accordance with the general method of example 48 from 8-(3,5-bis-trifluoromethyl-benzoyl)-3-(2-hydroxy-ethyl)-1-phenyl-1,3,8-triaza-spiro[4.5]decan-4-one and 1-methylpiperazine.

Sources & evidence

ORD record: ord-34ae92d78d4b4fcdaf2a7c8c9fe3bd5d
Source dataset: uspto-grants-2002_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06482829B2

Reaction notes

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