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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1018569Generated: October 30, 2026

Methyl Acrylate → 3-[8-(3,5-Bis-trifluoromethyl-benzoyl)-4-oxo-1-phenyl-1,3,8-triaza-spiro[4.5]dec-3-yl]-propionic acid methyl ester

https://huagongshe.com/reaction/1018569

Reaction equation

Participants

RoleNameHCIDCharge
ReactantMethyl AcrylateHCID 7294—
Reactant8-(3,5-Bis-trifluoromethyl-benzoyl)-1-phenyl-1,3,8-triaza-spiro[4.5]decan-4-oneHCID 18401725—
Product3-[8-(3,5-Bis-trifluoromethyl-benzoyl)-4-oxo-1-phenyl-1,3,8-triaza-spiro[4.5]dec-3-yl]-propionic acid methyl esterHCID 86584184—

Reaction Steps

The title compound, MS: m/e=558.2 (M+H+), was prepared in accordance with the general method of example 59 from 8-(3,5-bis-trifluoromethyl-benzoyl)-1-phenyl-1,3,8-triaza-spiro[4.5]decan-4-one and methyl acrylate.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06482829B2
Source datasetuspto-grants-2002_11
ORD IDord-d087d74983c54e8d926f539ee456e14e
Source noteuspto-grants-2002_11