Bromomethylcyclopropane → HCID 88183576, compound

HRID 1018592Notes

Reaction equation

C(N1[CH2:13][CH2:12][C:11](=O)[CH2:10]C1)C1C=CC=CC=1.[F:15][C:16]([F:48])([F:47])[C:17]1[CH:18]=[C:19]([CH:40]=[C:41]([C:43]([F:46])([F:45])[F:44])[CH:42]=1)[C:20]([N:22]1[CH2:39][CH2:38][C:25]2([N:29]([C:30]3[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=3)[CH:28]([CH3:36])[NH:27][C:26]2=[O:37])[CH2:24][CH2:23]1)=[O:21].C1(CBr)CC1>>[F:48][C:16]([F:15])([F:47])[C:17]1[CH:18]=[C:19]([CH:40]=[C:41]([C:43]([F:46])([F:45])[F:44])[CH:42]=1)[C:20]([N:22]1[CH2:23][CH2:24][C:25]2([N:29]([C:30]3[CH:31]=[CH:32][CH:33]=[CH:34][CH:35]=3)[CH:28]([CH3:36])[N:27]([CH2:10][CH:11]3[CH2:13][CH2:12]3)[C:26]2=[O:37])[CH2:38][CH2:39]1)=[O:21]

Participants

Reactant 2

HCID 81503Bromomethylcyclopropane

HCID 131723644HCID 131723644, compound

Product 1

HCID 88183576HCID 88183576, compound

Procedure

The title compound, MS: m/e=540.3 (M+H+), was prepared in accordance with the general method of example 99 from (rac)-8-(3,5-bis-trifluoromethyl-benzoyl)-2-methyl-1-phenyl-1,3,8-triaza-spiro[4.5]decan-4-one 1-benzyl-piperidin-4-one and cyclopropyl methyl bromide.

Sources & evidence

ORD record: ord-3c03c107fefc4827a1c9b898e88e098c
Source dataset: uspto-grants-2002_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06482829B2

Reaction notes

Loading…