(5-Methyl-1,2-oxazol-3-yl)methanol → 8-(3,5-Bis-trifluoromethyl-benzoyl)-3-(5-methyl-isoxazol-3-yl-methyl)-1-o-tolyl-1,3,8-triaza-spiro[4.5]decane-2,4-dione

HRID 1018606Notes

Reaction equation

HRID 1018606 reaction equation
[F:1][C:2]([F:35])([F:34])[C:3]1[CH:4]=[C:5]([CH:27]=[C:28]([C:30]([F:33])([F:32])[F:31])[CH:29]=1)[C:6]([N:8]1[CH2:26][CH2:25][C:11]2([N:15]([C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=3[CH3:22])[C:14](=[O:23])[NH:13][C:12]2=[O:24])[CH2:10][CH2:9]1)=[O:7].[CH3:36][C:37]1[O:41][N:40]=[C:39]([CH2:42]O)[CH:38]=1>>[F:35][C:2]([F:1])([F:34])[C:3]1[CH:4]=[C:5]([CH:27]=[C:28]([C:30]([F:33])([F:32])[F:31])[CH:29]=1)[C:6]([N:8]1[CH2:26][CH2:25][C:11]2([N:15]([C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=3[CH3:22])[C:14](=[O:23])[N:13]([CH2:42][C:39]3[CH:38]=[C:37]([CH3:36])[O:41][N:40]=3)[C:12]2=[O:24])[CH2:10][CH2:9]1)=[O:7]

Participants

3

Reactant 2

HCID 2736567(5-Methyl-1,2-oxazol-3-yl)methanolHCID 101177418-(3,5-Bis-trifluoromethyl-benzoyl)-1-o-tolyl-1,3,8-triaza-spiro[4.5]decane-2,4-dione

Product 1

HCID 184016798-(3,5-Bis-trifluoromethyl-benzoyl)-3-(5-methyl-isoxazol-3-yl-methyl)-1-o-tolyl-1,3,8-triaza-spiro[4.5]decane-2,4-dione

Procedure

The title compound, MS: m/e=595.0 (M+), was prepared in accordance with the general method of example 121 from 8-(3,5-bis-trifluoromethyl-benzoyl)-1-o-tolyl-1,3,8-triaza-spiro[4.5]decane-2,4-dione and 5-methylisoxazole-3-methanol.

Sources & evidence

ORD record
ord-164a949fd8e94b45ad002ba3256d9f36
Source dataset
uspto-grants-2002_11
Patent number
US06482829B2

Reaction notes

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