HRID1018606

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID2736567

(5-methylisoxazol-3-yl)methanol

C5H7NO2

结构：Cc1ccccc1N1C(=O)NC(=O)C12CCN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)CC2

HCID10117741

未命名化合物

PRODUCTS

生成物

结构：Cc1cc(CN2C(=O)N(c3ccccc3C)C3(CCN(C(=O)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)CC3)C2=O)no1

HCID18401679

未命名化合物

PROCEDURE

实验过程

The title compound, MS: m/e=595.0 (M+), was prepared in accordance with the general method of example 121 from 8-(3,5-bis-trifluoromethyl-benzoyl)-1-o-tolyl-1,3,8-triaza-spiro[4.5]decane-2,4-dione and 5-methylisoxazole-3-methanol.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-164a949fd8e94b45ad002ba3256d9f36
来源数据集: uspto-grants-2002_11
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06482829B2
来源说明: uspto-grants-2002_11

反应 SMILES

[F:1][C:2]([F:35])([F:34])[C:3]1[CH:4]=[C:5]([CH:27]=[C:28]([C:30]([F:33])([F:32])[F:31])[CH:29]=1)[C:6]([N:8]1[CH2:26][CH2:25][C:11]2([N:15]([C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=3[CH3:22])[C:14](=[O:23])[NH:13][C:12]2=[O:24])[CH2:10][CH2:9]1)=[O:7].[CH3:36][C:37]1[O:41][N:40]=[C:39]([CH2:42]O)[CH:38]=1>>[F:35][C:2]([F:1])([F:34])[C:3]1[CH:4]=[C:5]([CH:27]=[C:28]([C:30]([F:33])([F:32])[F:31])[CH:29]=1)[C:6]([N:8]1[CH2:26][CH2:25][C:11]2([N:15]([C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=3[CH3:22])[C:14](=[O:23])[N:13]([CH2:42][C:39]3[CH:38]=[C:37]([CH3:36])[O:41][N:40]=3)[C:12]2=[O:24])[CH2:10][CH2:9]1)=[O:7]