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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1018606Generated: November 1, 2026

(5-Methyl-1,2-oxazol-3-yl)methanol → 8-(3,5-Bis-trifluoromethyl-benzoyl)-3-(5-methyl-isoxazol-3-yl-methyl)-1-o-tolyl-1,3,8-triaza-spiro[4.5]decane-2,4-dione

https://huagongshe.com/reaction/1018606

Reaction equation

Participants

RoleNameHCIDCharge
Reactant(5-Methyl-1,2-oxazol-3-yl)methanolHCID 2736567—
Reactant8-(3,5-Bis-trifluoromethyl-benzoyl)-1-o-tolyl-1,3,8-triaza-spiro[4.5]decane-2,4-dioneHCID 10117741—
Product8-(3,5-Bis-trifluoromethyl-benzoyl)-3-(5-methyl-isoxazol-3-yl-methyl)-1-o-tolyl-1,3,8-triaza-spiro[4.5]decane-2,4-dioneHCID 18401679—

Reaction Steps

The title compound, MS: m/e=595.0 (M+), was prepared in accordance with the general method of example 121 from 8-(3,5-bis-trifluoromethyl-benzoyl)-1-o-tolyl-1,3,8-triaza-spiro[4.5]decane-2,4-dione and 5-methylisoxazole-3-methanol.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06482829B2
Source datasetuspto-grants-2002_11
ORD IDord-164a949fd8e94b45ad002ba3256d9f36
Source noteuspto-grants-2002_11