Phenylboronic Acid → Rac-8-(3,5-bis-trifluoromethyl-benzoyl)-2-methyl-3-phenyl-1-o-tolyl-1,3,8-triaza-spiro[4.5]decan-4-one

HRID 1018608Notes

Reaction equation

HRID 1018608 reaction equation
[F:1][C:2]([F:35])([F:34])[C:3]1[CH:4]=[C:5]([CH:27]=[C:28]([C:30]([F:33])([F:32])[F:31])[CH:29]=1)[C:6]([N:8]1[CH2:26][CH2:25][C:11]2([N:15]([C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=3[CH3:22])[CH:14]([CH3:23])[NH:13][C:12]2=[O:24])[CH2:10][CH2:9]1)=[O:7].[C:36]1(B(O)O)[CH:41]=[CH:40][CH:39]=[CH:38][CH:37]=1>>[F:35][C:2]([F:1])([F:34])[C:3]1[CH:4]=[C:5]([CH:27]=[C:28]([C:30]([F:33])([F:32])[F:31])[CH:29]=1)[C:6]([N:8]1[CH2:9][CH2:10][C:11]2([N:15]([C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=3[CH3:22])[CH:14]([CH3:23])[N:13]([C:36]3[CH:41]=[CH:40][CH:39]=[CH:38][CH:37]=3)[C:12]2=[O:24])[CH2:25][CH2:26]1)=[O:7]

Participants

3

Reactant 2

HCID 66827Phenylboronic AcidHCID 10163903(Rac)-8-(3,5-bis-trifluoromethyl-benzoyl)-2-methyl-1-o-tolyl-1,3,8-triaza-spiro[4.5]decan-4-one

Product 1

HCID 87854069Rac-8-(3,5-bis-trifluoromethyl-benzoyl)-2-methyl-3-phenyl-1-o-tolyl-1,3,8-triaza-spiro[4.5]decan-4-one

Procedure

The title compound, MS: m/e=576.0 (M+H+), was prepared in accordance with the general method of example 62 from (rac)-8-(3,5-bis-trifluoromethyl-benzoyl)-2-methyl-1-o-tolyl-1,3,8-triaza-spiro[4.5]decan-4-one and 4 phenylboronic acid.

Sources & evidence

ORD record
ord-b2133c7c6f3f4edb8522713d232d94a0
Source dataset
uspto-grants-2002_11
Patent number
US06482829B2

Reaction notes

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