HRID1018608

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID66827

Boronic acid, phenyl-

C6H7BO2

反应SMILES：Cc1ccccc1N1C(C)NC(=O)C12CCN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)CC2

HCID10163903

未命名化合物

PRODUCTS

产物

反应SMILES：Cc1ccccc1N1C(C)N(c2ccccc2)C(=O)C12CCN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)CC2

HCID87854069

未命名化合物

PROCEDURE

实验过程

The title compound, MS: m/e=576.0 (M+H+), was prepared in accordance with the general method of example 62 from (rac)-8-(3,5-bis-trifluoromethyl-benzoyl)-2-methyl-1-o-tolyl-1,3,8-triaza-spiro[4.5]decan-4-one and 4 phenylboronic acid.

来源与证据

来源类型: Open Reaction Database
ORD记录: ord-b2133c7c6f3f4edb8522713d232d94a0
来源数据集: uspto-grants-2002_11
DOI: 10.6084/m9.figshare.5104873.v1
专利号: US06482829B2
来源说明: uspto-grants-2002_11

反应SMILES

[F:1][C:2]([F:35])([F:34])[C:3]1[CH:4]=[C:5]([CH:27]=[C:28]([C:30]([F:33])([F:32])[F:31])[CH:29]=1)[C:6]([N:8]1[CH2:26][CH2:25][C:11]2([N:15]([C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=3[CH3:22])[CH:14]([CH3:23])[NH:13][C:12]2=[O:24])[CH2:10][CH2:9]1)=[O:7].[C:36]1(B(O)O)[CH:41]=[CH:40][CH:39]=[CH:38][CH:37]=1>>[F:35][C:2]([F:1])([F:34])[C:3]1[CH:4]=[C:5]([CH:27]=[C:28]([C:30]([F:33])([F:32])[F:31])[CH:29]=1)[C:6]([N:8]1[CH2:9][CH2:10][C:11]2([N:15]([C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=3[CH3:22])[CH:14]([CH3:23])[N:13]([C:36]3[CH:41]=[CH:40][CH:39]=[CH:38][CH:37]=3)[C:12]2=[O:24])[CH2:25][CH2:26]1)=[O:7]