2-(chloromethyl)-1-methyl-1H-imidazole → 8-(3,5-Bis-trifluoromethyl-benzoyl)-3-(1-methyl-1H-imidazol-2-yl-methyl)-1-o-tolyl-1,3,8-triaza-spiro[4.5]decan-4-one

HRID 1018614Notes

Reaction equation

HRID 1018614 reaction equation
[F:1][C:2]([F:34])([F:33])[C:3]1[CH:4]=[C:5]([CH:26]=[C:27]([C:29]([F:32])([F:31])[F:30])[CH:28]=1)[C:6]([N:8]1[CH2:25][CH2:24][C:11]2([N:15]([C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=3[CH3:22])[CH2:14][NH:13][C:12]2=[O:23])[CH2:10][CH2:9]1)=[O:7].Cl[CH2:36][C:37]1[N:38]([CH3:42])[CH:39]=[CH:40][N:41]=1>>[F:34][C:2]([F:1])([F:33])[C:3]1[CH:4]=[C:5]([CH:26]=[C:27]([C:29]([F:32])([F:31])[F:30])[CH:28]=1)[C:6]([N:8]1[CH2:25][CH2:24][C:11]2([N:15]([C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=3[CH3:22])[CH2:14][N:13]([CH2:36][C:37]3[N:38]([CH3:42])[CH:39]=[CH:40][N:41]=3)[C:12]2=[O:23])[CH2:10][CH2:9]1)=[O:7]

Participants

3

Reactant 2

HCID 7365362-(chloromethyl)-1-methyl-1H-imidazoleHCID 101631378-(3,5-Bis-trifluoromethyl-benzoyl)-1-o-tolyl-1,3,8-triaza-spiro[4.5]decan-4-one

Product 1

HCID 865841868-(3,5-Bis-trifluoromethyl-benzoyl)-3-(1-methyl-1H-imidazol-2-yl-methyl)-1-o-tolyl-1,3,8-triaza-spiro[4.5]decan-4-one

Procedure

The title compound, MS: m/e=580.3 (M+H+), was prepared in accordance with the general method of example 99 from 8-(3,5-bis-trifluoromethyl-benzoyl)-1-o-tolyl-1,3,8-triaza-spiro[4.5]decan-4-one and 2-chloromethyl-1-methyl-1H-imidazole.

Sources & evidence

ORD record
ord-6ccc16fb87cd40468f1b05670c6265ef
Source dataset
uspto-grants-2002_11
Patent number
US06482829B2

Reaction notes

Loading…