HRID1018614

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID736536

2-(chloromethyl)-1-methyl-1H-imidazole

C5H7ClN2

结构：Cc1ccccc1N1CNC(=O)C12CCN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)CC2

HCID10163137

未命名化合物

PRODUCTS

生成物

结构：Cc1ccccc1N1CN(Cc2nccn2C)C(=O)C12CCN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)CC2

HCID86584186

未命名化合物

PROCEDURE

实验过程

The title compound, MS: m/e=580.3 (M+H+), was prepared in accordance with the general method of example 99 from 8-(3,5-bis-trifluoromethyl-benzoyl)-1-o-tolyl-1,3,8-triaza-spiro[4.5]decan-4-one and 2-chloromethyl-1-methyl-1H-imidazole.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-6ccc16fb87cd40468f1b05670c6265ef
来源数据集: uspto-grants-2002_11
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06482829B2
来源说明: uspto-grants-2002_11

反应 SMILES

[F:1][C:2]([F:34])([F:33])[C:3]1[CH:4]=[C:5]([CH:26]=[C:27]([C:29]([F:32])([F:31])[F:30])[CH:28]=1)[C:6]([N:8]1[CH2:25][CH2:24][C:11]2([N:15]([C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=3[CH3:22])[CH2:14][NH:13][C:12]2=[O:23])[CH2:10][CH2:9]1)=[O:7].Cl[CH2:36][C:37]1[N:38]([CH3:42])[CH:39]=[CH:40][N:41]=1>>[F:34][C:2]([F:1])([F:33])[C:3]1[CH:4]=[C:5]([CH:26]=[C:27]([C:29]([F:32])([F:31])[F:30])[CH:28]=1)[C:6]([N:8]1[CH2:25][CH2:24][C:11]2([N:15]([C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=3[CH3:22])[CH2:14][N:13]([CH2:36][C:37]3[N:38]([CH3:42])[CH:39]=[CH:40][N:41]=3)[C:12]2=[O:23])[CH2:10][CH2:9]1)=[O:7]