HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-(chloromethyl)-1-methyl-1H-imidazole → 8-(3,5-Bis-trifluoromethyl-benzoyl)-3-(1-methyl-1H-imidazol-2-yl-methyl)-1-o-tolyl-1,3,8-triaza-spiro[4.5]decan-4-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-(chloromethyl)-1-methyl-1H-imidazole | HCID 736536 | — |
| Reactant | 8-(3,5-Bis-trifluoromethyl-benzoyl)-1-o-tolyl-1,3,8-triaza-spiro[4.5]decan-4-one | HCID 10163137 | — |
| Product | 8-(3,5-Bis-trifluoromethyl-benzoyl)-3-(1-methyl-1H-imidazol-2-yl-methyl)-1-o-tolyl-1,3,8-triaza-spiro[4.5]decan-4-one | HCID 86584186 | — |
Reaction Steps
The title compound, MS: m/e=580.3 (M+H+), was prepared in accordance with the general method of example 99 from 8-(3,5-bis-trifluoromethyl-benzoyl)-1-o-tolyl-1,3,8-triaza-spiro[4.5]decan-4-one and 2-chloromethyl-1-methyl-1H-imidazole.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06482829B2 |
| Source dataset | uspto-grants-2002_11 |
| ORD ID | ord-6ccc16fb87cd40468f1b05670c6265ef |
| Source note | uspto-grants-2002_11 |