Bromomethylcyclopropane → HCID 18401646, compound

HRID 1018617Notes

Reaction equation

[F:1][C:2]([F:34])([F:33])[C:3]1[CH:4]=[C:5]([CH:26]=[C:27]([C:29]([F:32])([F:31])[F:30])[CH:28]=1)[C:6]([N:8]1[CH2:25][CH2:24][C:11]2([N:15]([C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=3[CH3:22])[C:14](=[O:23])[NH:13][CH2:12]2)[CH2:10][CH2:9]1)=[O:7].[CH:35]1([CH2:38]Br)[CH2:37][CH2:36]1>>[F:34][C:2]([F:1])([F:33])[C:3]1[CH:4]=[C:5]([CH:26]=[C:27]([C:29]([F:32])([F:31])[F:30])[CH:28]=1)[C:6]([N:8]1[CH2:25][CH2:24][C:11]2([N:15]([C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=3[CH3:22])[C:14](=[O:23])[N:13]([CH2:38][CH:35]3[CH2:37][CH2:36]3)[CH2:12]2)[CH2:10][CH2:9]1)=[O:7]

Participants

Reactant 2

HCID 81503Bromomethylcyclopropane

HCID 18401720HCID 18401720, compound

Product 1

HCID 18401646HCID 18401646, compound

Procedure

The title compound, MS: m/e=540.4 (M+H+), was prepared in accordance with the general method of example 99 from 8-(3,5-bis-trifluoromethyl-benzoyl)-1-o-tolyl-1,3,8-triaza-spiro[4.5]decan-2-one and cyclopropyl methyl bromide.

Sources & evidence

ORD record: ord-27c32624493247af84a5d19ad4791d83
Source dataset: uspto-grants-2002_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06482829B2

Reaction notes

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