2-Chloroethyl methyl ether → HCID 87854879, compound

HRID 1018632Notes

Reaction equation

HRID 1018632 reaction equation
[F:1][C:2]([F:33])([F:32])[C:3]1[CH:4]=[C:5]([CH:25]=[C:26]([C:28]([F:31])([F:30])[F:29])[CH:27]=1)[C:6]([N:8]1[CH2:24][CH2:23][C:11]2([C:15](=[O:16])[NH:14][CH2:13][CH:12]2[C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)[CH2:10][CH2:9]1)=[O:7].Cl[CH2:35][CH2:36][O:37][CH3:38]>>[F:31][C:28]([F:29])([F:30])[C:26]1[CH:25]=[C:5]([CH:4]=[C:3]([C:2]([F:1])([F:32])[F:33])[CH:27]=1)[C:6]([N:8]1[CH2:9][CH2:10][C:11]2([C:15](=[O:16])[N:14]([CH2:35][CH2:36][O:37][CH3:38])[CH2:13][CH:12]2[C:17]2[CH:18]=[CH:19][CH:20]=[CH:21][CH:22]=2)[CH2:23][CH2:24]1)=[O:7]

Participants

3

Reactant 2

HCID 123162-Chloroethyl methyl etherHCID 22898542HCID 22898542, compound

Product 1

HCID 87854879HCID 87854879, compound

Procedure

The title compound, MS: m/e=529.2 (M+H+), was prepared in accordance with the general method of example 99 from (rac)-8-(3,5-bis-trifluoromethyl-benzoyl)-4-phenyl-2,8-diaza-spiro[4.5]decan-1-one and 2-chloroethyl-methyl-ether.

Sources & evidence

ORD record
ord-76e6e49a337d4f5faa2ef3c4633e03ce
Source dataset
uspto-grants-2002_11
Patent number
US06482829B2

Reaction notes

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