Trifluoroacetic acid → HCID 70156341, compound

HRID 1018682Notes

Reaction equation

HRID 1018682 reaction equation
C(OC([NH:8][C@@H:9]1[C:15]2[CH:16]=[C:17]([C:28]([NH2:30])=[O:29])[C:18]([O:20][CH2:21][CH:22]3[CH2:27][CH2:26][CH2:25][CH2:24][CH2:23]3)=[CH:19][C:14]=2[CH2:13][CH2:12][CH2:11][CH2:10]1)=O)(C)(C)C.C(O)(C(F)(F)F)=O>C(Cl)Cl>[NH2:8][C@@H:9]1[C:15]2[CH:16]=[C:17]([C:28]([NH2:30])=[O:29])[C:18]([O:20][CH2:21][CH:22]3[CH2:23][CH2:24][CH2:25][CH2:26][CH2:27]3)=[CH:19][C:14]=2[CH2:13][CH2:12][CH2:11][CH2:10]1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 70154445HCID 70154445, compound

Product 1

HCID 70156341HCID 70156341, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a cooled (0° C.) solution of (S)-9-tert-butoxycarbonylamino-3-cyclohexylmethoxy-6,7,8,9-tetrahydro-5H-benzocycloheptene-2-carboxylic acid amide (198 mg, 0.475 mmol) in DCM (1 mL) was added TFA (1 mL). After 10 min, the reaction was allowed to warm to rt and after 1 h, the reaction was evaporated to dryness. The material was used without further purification for the next step.

Workup

  1. customthe reaction was evaporated to dryness
  2. customThe material was used without further purification for the next step

Sources & evidence

ORD record
ord-b0c39e817d0d4a27b843b4a2b5924239
Source dataset
uspto-grants-2002_11
Patent number
US06482852B2

Reaction notes

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