Pyridine → Acetamide, N-(3,5-dichlorophenyl)-

HRID 1018795Notes

Reaction equation

HRID 1018795 reaction equation
N1C=CC=CC=1.[Cl:7][C:8]1[CH:9]=[C:10]([NH2:15])[CH:11]=[C:12]([Cl:14])[CH:13]=1.[C:16](OC(=O)C)(=[O:18])[CH3:17]>C(Cl)(Cl)Cl>[Cl:7][C:8]1[CH:9]=[C:10]([NH:15][C:16](=[O:18])[CH3:17])[CH:11]=[C:12]([Cl:14])[CH:13]=1

Participants

5

Reactant 3

HCID 1049PyridineHCID 7918Acetic AnhydrideHCID 122813,5-Dichloroaniline

Product 1

HCID 182054Acetamide, N-(3,5-dichlorophenyl)-

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

200 ml of pyridine are added dropwise to 100 g of 3,5-dichlorophenylamine in 3000 ml of chloroform, followed by addition of 90 ml of acetic anhydride. The reaction mixture is stirred for 12 hours at room temperature. The solvents are evaporated off under reduced pressure and the residue obtained is recrystallized from 1000 ml of ethyl acetate; m.p.=182° C.

Workup

  1. customThe solvents are evaporated off under reduced pressure
  2. customthe residue obtained
  3. customis recrystallized from 1000 ml of ethyl acetate

Sources & evidence

ORD record
ord-8aaa631de4e64c6eab26d209db2f0332
Source dataset
uspto-grants-2002_11
Patent number
US06482986B1

Reaction notes

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