Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Propargyl bromide | HCID 7842 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 2-Cyclohexylethylamine | HCID 20509 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | HCID 62142207 | HCID 62142207 | — |
Reaction Steps
20 ml of 80% 3-bromopropyne are added dropwise to 30.3 ml of cyclohexylethylamine and 29.7 g of potassium carbonate in 300 ml of acetonitrile. The reaction mixture is heated at 50° C. for 12 hours and at 80° C. for 6 hours. The resulting mixture is filtered and the solvents are evaporated off under reduced pressure. Compound V.1 is purified by distillation.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US06482986B1 |
|---|
| Source dataset | uspto-grants-2002_11 |
|---|
| ORD ID | ord-27b931c3ac864ae2949ced68c36bd346 |
|---|
| Source note | uspto-grants-2002_11 |
|---|
