Propargyl bromide → HCID 62142207, compound

HRID 1018805Notes

Reaction equation

HRID 1018805 reaction equation
Br[CH2:2][C:3]#[CH:4].[CH:5]1([CH2:11][CH2:12][NH2:13])[CH2:10][CH2:9][CH2:8][CH2:7][CH2:6]1.C(=O)([O-])[O-].[K+].[K+]>C(#N)C>[CH:5]1([CH2:11][CH2:12][NH:13][CH2:4][C:3]#[CH:2])[CH2:10][CH2:9][CH2:8][CH2:7][CH2:6]1

Participants

5

Reactant 3

HCID 7842Propargyl bromideHCID 11430Potassium CarbonateHCID 205092-Cyclohexylethylamine

Product 1

HCID 62142207HCID 62142207, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Conditions

Temperature
80 °C

Procedure

20 ml of 80% 3-bromopropyne are added dropwise to 30.3 ml of cyclohexylethylamine and 29.7 g of potassium carbonate in 300 ml of acetonitrile. The reaction mixture is heated at 50° C. for 12 hours and at 80° C. for 6 hours. The resulting mixture is filtered and the solvents are evaporated off under reduced pressure. Compound V.1 is purified by distillation.

Workup

  1. filtrationThe resulting mixture is filtered
  2. customthe solvents are evaporated off under reduced pressure
  3. distillationCompound V.1 is purified by distillation

Sources & evidence

ORD record
ord-27b931c3ac864ae2949ced68c36bd346
Source dataset
uspto-grants-2002_11
Patent number
US06482986B1

Reaction notes

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