O-Methylhydroxylamine → HCID 72591133, compound

HRID 1018819Notes

Reaction equation

HRID 1018819 reaction equation
[CH3:1][O:2][N:3]=[C:4]([C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=1[CH2:15][O:16][C:17]1[CH:22]=[CH:21][C:20]([O:23][CH:24]([CH3:28])[C:25](=O)[CH3:26])=[CH:19][C:18]=1[CH3:29])[C:5]([NH:7][CH3:8])=[O:6].[CH3:30][O:31][NH2:32]>CO>[CH3:1][O:2][N:3]=[C:4]([C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=1[CH2:15][O:16][C:17]1[CH:22]=[CH:21][C:20]([O:23][CH:24]([CH3:28])[C:25](=[N:32][O:31][CH3:30])[CH3:26])=[CH:19][C:18]=1[CH3:29])[C:5]([NH:7][CH3:8])=[O:6]

Participants

4

Reactant 2

HCID 4113O-MethylhydroxylamineHCID 72591136HCID 72591136, compound

Product 1

HCID 72591133HCID 72591133, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
22.5 °C

Procedure

A solution of 21.7 g of the compound from Example 3 in 100 ml of methanol was admixed with 30.4 g of 30% strength aqueous methoxyamine solution and then stirred at 20-25° C. for 12 h. The solvent was distilled off and the residue was taken up in a mixture of methyl tert-butyl ether/water, and the phases were then separated. After drying, the solvent was removed from the organic phase. The residue gave 22 g of the title compound as a light-brown oil.

Workup

  1. distillationThe solvent was distilled off
  2. additionthe residue was taken up in a mixture of methyl tert-butyl ether/water
  3. customthe phases were then separated
  4. customAfter drying
  5. customthe solvent was removed from the organic phase

Sources & evidence

ORD record
ord-6a367da89dcb4652a6739205e52cc9cf
Source dataset
uspto-grants-2002_11
Patent number
US06482984B2

Reaction notes

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