Diisopropyl Ether → HCID 178527942, compound

HRID 1018925Notes

Reaction equation

HRID 1018925 reaction equation
O[C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[C:5]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)=[N:4][N:3]=1.COC1C=CC(P2(SP(C3C=CC(OC)=CC=3)(=S)S2)=[S:27])=CC=1.C(OC(C)C)(C)C>C1(C)C=CC=CC=1>[C:12]1([C:5]2[C:6]3[C:11](=[CH:10][CH:9]=[CH:8][CH:7]=3)[C:2]([SH:27])=[N:3][N:4]=2)[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1

Participants

5

Reactant 3

HCID 7914Diisopropyl EtherHCID 87949Lawesson's reagentHCID 178518893HCID 178518893, compound

Product 1

HCID 178527942HCID 178527942, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

1-Hydroxy-4-phenylphthalazine (0.31 g, 1.5 mmol) in toluene (30 ml) is allowed to react with Lawesson's reagent (0.6 g, 1.5 mmol) and the mixture is stirred in an oil bath. (80-90° C.) for 1.5 hour until all starting material is used up. Evaporation of the solvent gives a yellow solid which is stirred with isopropyl ether. Filtration gives the title compound as a yellow solid which is recrystallized from hexane/THF/toluene:7.5/2.5/2.0 (0.3 g)

Workup

  1. customEvaporation of the solvent
  2. customgives a yellow solid which
  3. filtrationFiltration

Sources & evidence

ORD record
ord-e9bf17d23f5f46f482fcefe1e427aca8
Source dataset
uspto-grants-2002_11
Patent number
US06486158B1

Reaction notes

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